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; et al The vaccinia virus E3L gene product interacts with both the regulatory and the substrate binding regions of PKR: implications for PKR autoregulation Virology 1998, 250, 302 315 61 Romano, P R; Zhang, F; Tan, S-L; Garcia-Barrio, M T; Katze, M G; et al Inhibition of double-stranded RNA-dependent protein kinase PKR by vaccinia virus E3:.

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By allocating resources at ow level, or more exactly, by rejecting newly arriving ows when available capacity is exhausted, quality of service provision is decomposed into two parts: service mechanisms and control protocols ensure that the quality of service of accepted ows is satisfactory; traf c engineering is applied to dimension network elements so that the probability of rejection remains tolerably small The present chapter aims to demonstrate that this approach is feasible, sacri cing detail and depth somewhat in favor of a broad view of the range of issues that need to be addressed conjointly Other chapters in this book are particularly relevant to the present discussion In 19, Adas and Mukherjee propose a framing scheme to ensure guaranteed quality for services like video transmission while Tuan and Park in 18 study congestion control algorithms for ``elastic'' data communications.

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that elicit acute toxicity, toxicity observed at the higher dosage may simply re ect acute, and not chronic, toxicity (Figure 11.2). Effects encountered with acute toxicity commonly consist of mortality or morbidity. From a quantitative standpoint these effects are measured as the LD50, ED50, LC50, or EC50. The LD50 and ED50 represent the dose of the material that causes mortality (LD50) or some other de ned effect (ED50) in 50% of a treated population. The LC50 and EC50 represent the concentration of the material to which the organisms were exposed that causes mortality (LC50) or some other de ned effect (EC50) in 50% of an exposed population. LD50 and ED50 are normalize to the weight of the animal (i.e., mg chemical/kg body weight); whereas LC50 and EC50 are normalized to the environment in which the organisms were exposed (i.e., mg chemical/L water).

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role of complex formation and the E3 N-terminal domain Mol Cell Biol 1998, 18, 7304 7316 62 Rivas, C; Gil, J; Melkova, Z; Esteban, M; Diaz-Guerra, M Vaccinia virus E3L protein is an inhibitor of the interferon (IFN)-induced 2-5A synthetase enzyme Virology 1998, 243, 406 414 63 Lee, T G; Tomita, J; Hovanessian, A G; Katze, M G Characterization and regulation of the 58,000-dalton cellular inhibitor of the interferon-induced, dsRNA-activated protein kinase J Biol Chem 1992, 267, 14238 14243 64 Lee, T G; Tomita, J; Hovanessian, A G; Katze, M G Puri cation and partial characterization of a cellular inhibitor of the interferon-induced protein kinase of Mr 68,000 from in uenza virus-infected cells Proc Natl Acad Sci USA 1990, 87, 6208 6212 65 Lee, T G; Tang, N; Thompson, S; Miller, J; Katze, M.

Naturally, the schemes in both chapters take account of the self-similar nature of the considered traf c ows They constitute alternatives to our own proposals 15 by Feldmann gives a very precise description of Internet traf c characteristics at ow level, which to some extent invalidates our too optimistic Poisson arrivals assumption The latter assumption remains useful, however, notably in showing how heavytailed distributions do not lead to severe performance problems if closed-loop control is used to dynamically share resources as in a processor sharing queue The same Poisson approximation is exploited by Boxma and Cohen in 6, which contrasts the performance of FIFO (open-loop control) and processor sharing (PS) (closed-loop control) queues with heavy-tailed job sizes In the next section we discuss the nature of traf c in a multiservice network, identifying broad categories of ows with distinct quality of service requirements.

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