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The second type of traf c we consider consists of digital objects or ``documents,'' which must be transferred from one place to another These documents might be data les, texts, pictures, or video sequences transferred for local storage before viewing This traf c is elastic in that the ow rate can vary due to external causes (eg, bandwidth availability) without detrimental effect on quality of service Users may or may not have quality of service requirements with respect to throughput They do for real-time information retrieval sessions, where it is important for documents to appear rapidly on the user's screen They do not for e-mail or le transfers where deferred delivery, within a loose time limit, is perfectly acceptable The essential characteristics of elastic traf c are the arrival process of transfer requests and the distribution of object sizes.

76 Schroder, H C; Wenger, R; Rottman, M; Muller, W E G Alteration of nuclear (20 -50 )oligoriboadenylate synthetase and nuclease activities preceding replication of human immunode ciency virus in H9 cells Biol Chem Hoppe-Seyler 1988, 369, 985 995 77 Silverman, R H; Cayley, P J; Knight, M; Gilbert, C S; Kerr, I M Control of the ppp(a20 p)nA system in HeLa cells Effects of interferon and virus infection Eur J Biochem 1982, 124(1), 131 138 78 Bisbal, C; Martinand, C; Silhol, M; Lebleu, B; Salehzada, T Cloning and characterization of a RNAse L inhibitor A new component of the interferon-regulated 2-5A pathway J Biol Chem 1995, 270(22), 13308 13317 79 Martinand, C; Salehzada, T; Silhol, M; Lebleu B; Bisbal, C.

Metering Orifice Baffle Plates Aerosol Generating System Exposure Tube Line Valves Filter Chamber Orifice Magnehelic Gauge Temperature/Relative Humidity Sensor Vaccum Hepa Filter

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Observations on Web traf c provide useful pointers to the nature of these characteristics [2, 5] The average arrival intensity of transfer requests varies depending on underlying user activity patterns As for stream traf c, it should be possible to identify representative busy periods, where the arrival process can be considered to be stationary Measurements on Web sites reported by Arlitt and Williamson [2] suggest the possibility of modeling the arrivals as a Poisson process A Poisson process indeed results naturally when members of a very large population of users independently make relatively widely spaced demands Note, however, that more recent and thorough measurements suggest that the Poisson assumption may be too optimistic (see 15) Statistics on the size of Web documents reveal that they are extremely variable, exhibiting a heavy-tailed probability distribution.

Most objects are very small: measurements on Web document sizes reported by Arlitt and Williamson reveal that some 70% are less than 1 kbyte and only around 5% exceed 10 kbytes The presence of a few extremely long documents has a signi cant impact on the overall traf c volume, however..

Figure 21.1 An inhalation exposure system (Modi ed from Adkins, B. et al. Am. Int. Hyg. Assoc. J. 41: 494, 1980.)

RNase L inhibitor (RLI) antisense constructions block partially the downregulation of the 2-5A/RNase L pathway in encephalomyocarditis-virus-(EMCV)-infected cells Eur J Biochem 1998, 254(2), 248 255 80 Martinand, C; Montavon, C; Salehzada, T; Silhol, M; Lebleu, B; Bisbal, C RNase L inhibitor is induced during human immunode ciency virus type 1 infection and down regulates the 2-5A/RNase L pathway in human T cells J Virol 1999, 73(1), 290 296 81 Martinand, C; Salehzada, T; Silhol, M; Lebleu, B; Bisbal, C The RNase L inhibitor (RLI) is induced by double-stranded RNA J Interferon Cytokine Res 1998, 18(12), 1031 1038 82 Bisbal, C; Salehzada, T; Silhol, M; Martinand, C; Le Roy, F; Lebleu, B The 2-5A/ RNase L pathway and inhibition by RNase L inhibitor (RLI) Methods Mol Biol 2001, 160, 183 198 83 Le Roy, F.

It is possible to de ne a notion of traf c demand for elastic ows, in analogy with the de nition given above for stream traf c, as the product of an average arrival rate in a representative busy period and the average object size.

materials over an extended period is also possible. Again, both solvent controls and untreated controls are necessary for proper interpretation of the results.

; Bisbal, C; Silhol, M; Martinand, C; Lebleu, B; Salehzada, T The 2-5A/ RNase L/RNase L inhibitor (RLI) [correction of (RNI)] pathway regulates mitochondrial mRNAs stability in interferon alpha-treated H9 cells J Biol Chem 2001, 276(51), 48473 48482 84 Kerr, I D Sequence analysis of twin ATP binding cassette proteins involved intranslational control, antibiotic resistance, and ribonuclease L inhibition Biochem Biophys Res Commun 2004, 315(1), 166 173 85 Zimmerman, C; Klein, K C; Kiser, P K; Singh, A R; Firestein, B L; Riba S C; Lingappa, J R Identi cation of a host protein essential for assembly of immature HIV-1 capsids Nature 2002, 415, 88 92 86 Garcia-Sastre, A Inhibition of interferon-mediated antiviral responses by in uenza A viruses and other negative-strand RNA viruses Virology 2001 279(2), 375 384 87 Tan, S L; Katze, M G.

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